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This film examines the claim that most if not all degenerative diseases that afflict us can be controlled, or even reversed, by rejecting animal-based and processed foods. It traces the personal journeys of a pair of pioneering researchers, Dr. T. Colin Campbell and Dr. Caldwell Esselstyn. Although they didn't know each other, their individual research led to startlingly similar conclusions: degenerative diseases could usually be prevented--and in many cases reversed--by adopting a whole food, plant-based diet. Despite the profound implications of their findings, their work has remained relatively unknown to the public. The filmmakers explore the ancient idea of food as medicine, following "reality patients" who have adopted a whole foods plant-based diet as the primary approach to treat their ailments.